Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Matthew Grant, MD


Sepsis is a pervasive condition that carries a tremendous burden of disease in the form of financial cost, morbidity, and mortality. Culturing methods slow clinicians’ ability to begin focused treatment, and increased antimicrobial resistance only intensifies the need for improved diagnostic tools. Rapid molecular diagnostic tests can shorten time to identify organisms, reduce inappropriate antibiotic treatment, and improve patient outcomes. A newly approved test has proven fast and accurate for identification and susceptibility, but has not been studied in regard to clinical outcomes. Our study will compare the effect of the Accelerate™ system versus standard identification and susceptibility tests on patient length of stay. In a randomized controlled trial, we will use the Accelerate Pheno™ system to identify microbes and drug-resistance in septic critical care patients. We expect that diagnosis using this test will result in faster, more focused therapy, which will shorten hospital stays and save lives.

Open Access

This Article is Open Access