Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Lindsay C. Johnston, MD


Context: Neonatal sepsis is associated with prolonged hospital stay and increased morbidity and mortality despite appropriate antimicrobial therapy. There are discordant results in the existing literature regarding the association between adjunctive pentoxifylline therapy and duration of stay or mortality.

Hypothesis: We hypothesize that among preterm infants with blood culture-confirmed sepsis who are treated with pentoxifylline plus appropriate antimicrobial therapy, as compared to infants treated with placebo plus appropriate antimicrobial therapy, median duration of stay in the neonatal intensive care unit will be significantly reduced.

Methods: We propose a multicenter, double-blind, placebo-controlled, parallel-group randomized controlled trial to investigate the efficacy of adjunctive pentoxifylline therapy to reduce duration of stay in the neonatal intensive care unit.

Significance: Results from this study may identify an agent that can be added to antimicrobial therapy to reduce duration of stay and attenuate the associated morbidity, mortality, and socioeconomic and emotional burdens of neonatal sepsis.

Open Access

This Article is Open Access