Date of Award
Master of Medical Science (MMSc)
Arnar Geirsson, MD, FACS, FAHA
Type B aortic dissection is a potentially lethal condition of the aorta. Currently medical management involves aggressive blood pressure control using a variety of antihypertensive medications, reserving surgical or endovascular intervention for complications only. However, an optimal medical treatment regimen has not yet been established, and long-term outcomes remain poor. Growing evidence demonstrates that statins have beneficial pleiotropic effects in cardiovascular disease. In this prospective, randomized, placebo-controlled, double-blinded study, we determine whether the addition of a high-intensity statin to best medical therapy in adults with acute type B aortic dissections can decrease differential growth rate of the descending aorta over 18 months. The results of this study will allow clinicians to optimize medical therapy in the treatment of uncomplicated type B aortic dissections, reducing or eliminating the need for surgical intervention.
Chen, Tinley, "Evaluating the Utility of Atorvastatin for Best Medical Therapy in Stable Aortic Dissection" (2020). Yale School of Medicine Physician Associate Program Theses. 5.