Date of Award

Fall 9-20-2024

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Emily J. Gilmore, MD, FNCS, FACNS

Second Advisor

Sacit Bulent Omay, MD, FAAN

Abstract

Background: The purpose of this study was to examine whether patients, previously on anticoagulation (AC) therapy who have sustained traumatic intracranial hemorrhage (tICrH), had less composite thrombotic or hemorrhagic events from earlier resumption of AC therapy compared to patients resumed later. Methods: In this retrospective observational study, we explored the median time to AC resumption in patients who were admitted for tICrH. The median was used as the cutoff point for defining early vs. late resumption of AC. Patients were categorized into early if resumption occurred between 14 and 23 days, late if resumption occurred between 24-120 days, and never resumed if AC was never resumed or resumed after 120 days. The mean difference of composite events following injury was compared between the three groups. Results: There was a significant difference between the three groups in the mean number of composite events and thrombotic events. The mean number of composite events in the early resumption group was significantly less than that of the late resumption group (mean 0.05, SD 0.22 vs mean 0.27, SD 0.55; P=.015). The mean number of thrombotic events in the early resumption group was significantly less than that of the late resumption group (mean 0.03, SD 0.18 vs mean 0.19, SD 0.43; P=.024). Conclusion: Our results suggest events that occur following tICrH are largely thrombotic events and resuming AC earlier decreases such events from occurring. This adds to the evidence in support of earlier resumption of AC following tICrH.

Comments

This is an open access thesis.

Open Access

This Article is Open Access

Share

COinS