Date of Award

Summer 7-26-2024

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Jeffrey Turner, MD

Abstract

Heart failure is widespread and associated with high mortality and healthcare costs. Patients hospitalized with acute decompensated heart failure are at risk for developing kidney injury, a high-risk complication known as cardiorenal syndrome. Elevated uromodulin has reno-protective effects and is associated with a lower risk of kidney dysfunction. Compelling evidence suggests that elevations in uromodulin levels may help improve clinical outcomes among other kidney disease populations yet, it has not been explored in patients with heart failure. This study aims to investigate the relationship between baseline serum uromodulin levels and risk of incident acute kidney injury among acute decompensated heart failure patients with reduced left ventricular ejection fraction through a single-health system, prospective cohort design. Conclusions drawn from this study will provide insight on the prognostic and therapeutic utility of serum uromodulin, which may direct future research related to cardiorenal syndrome prevention and guideline-directed management strategies for this high-risk population.

Comments

This is an open access thesis.

Open Access

This Article is Open Access

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