Date of Award
Summer 6-14-2024
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
Timothy Belliveau, PhD, ABPP
Abstract
Selective head-neck cooling therapy as novel treatment for concussion has been researched in pilot studies for several years using symptom severity as the primary outcome. As of 2018, brain biomarkers glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been FDA approved as indicators of Traumatic Brain Injury (TBI). This study aims to investigate the effects of selective head-neck cooling therapy on the serum levels of the biomarkers, alongside patient symptom severity, in adults aged 18 years and older with mild Traumatic Brain Injury diagnosed in the last 72 hours. A randomized controlled trial will compare two intervention groups receiving selective head and neck cooling therapy for 30 minutes daily and 30 minutes every other day for 10 days, along with a control group receiving standard of care. This study seeks to fill a gap in the literature by exploring potential anti-neuroinflammatory effects of selective head-neck cooling therapy.
Recommended Citation
Conrado, Mateusz, "Effect of Selective Head-Neck Cooling Therapy on Specific Brain Biomarkers After Concussive Injury" (2024). Yale School of Medicine Physician Associate Program Theses. 213.
https://elischolar.library.yale.edu/ysmpa_theses/213
Comments
This is an open access thesis.