Date of Award
Spring 5-17-2024
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
Matthew Grant, MD, FIDSA
Abstract
Oropharyngeal candidiasis is the most prevalent opportunistic infection among people living with HIV. Fluconazole is the recommended treatment for the disease in immunocompromised patients, but its efficacy is waning with growing resistance of candida, the yeast that causes candidiasis. Studies have shown that probiotics decrease oral candida load, but research about the use of probiotics in HIV-positive individuals with oropharyngeal candidiasis is limited. This study will investigate whether probiotics taken with fluconazole lead to increased remission of oropharyngeal candidiasis signs and symptoms in subjects with HIV when compared to fluconazole monotherapy. Participants will be treated with a two-week fluconazole course and be randomly assigned to take probiotic or placebo lozenges. Clinical severity will be assessed weekly and the proportion of patients with clinical remission in both groups will be observed. If proven effective, probiotics offer a cheap and accessible adjunctive treatment for oropharyngeal candidiasis in this population.
Recommended Citation
Romaneschi, Nicole, "Effect of a Multispecies Probiotic with Fluconazole on Oral Candidiasis in Subjects with HIV" (2024). Yale School of Medicine Physician Associate Program Theses. 210.
https://elischolar.library.yale.edu/ysmpa_theses/210
Comments
This is an open access thesis.