Date of Award

Spring 4-19-2024

Document Type

Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Scott Casper, MD

Abstract

Polycystic ovarian syndrome and gestational diabetes are common yet distinct gynecologic conditions but share a common underlying mechanism: insulin resistance. Inositol, a natural sugar, demonstrates promising effects in managing polycystic ovarian syndrome, specifically improving insulin sensitivity. However, the effectiveness of inositol in lowering mean glucose levels in patients with gestational diabetes remains uncertain. We propose a double-blind randomized controlled trial to investigate the inositol’s potential to improve average glucose levels. Patients with polycystic ovarian syndrome and poorly controlled gestational diabetes will be randomized to receive either 40:1 Myo-inositol and D-Chiro-inositol twice daily or 500 milligrams of metformin twice daily. We hypothesize that patients assigned to inositol will demonstrate a significantly different improvement in average glucose levels compared to those managed with metformin. By investigating the efficacy of inositol, we aim to enhance treatment options and quality of life for women navigating two complex conditions who face limitations with traditional therapies.

Comments

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