Date of Award

Spring 4-19-2024

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Charles Wira, MD

Abstract

Targeted temperature management has been shown to improve neurologic status after cardiac arrest; however, recommendations for the timing of its initiation are unclear. Clinical trials have not directly studied time to targeted temperature management initiation, causing wide variability in protocol implementation. We propose a randomized, controlled, multi-center clinical trial to study the effect of early initiation of targeted temperature management in patients who achieve return of spontaneous circulation after out-of-hospital cardiac arrest. Data will be compared among patients who received initiation of targeted temperature management within 3 hours to those in whom initiation occurred after 3 hours. The primary outcome will be survival with favorable neurologic outcome, assessed at 6 months post-arrest with the use of the Cerebral Performance Category scale. These results may provide context for the interpretation of findings from previous trials in targeted temperature management, thereby potentially redefining guidelines for cardiac arrest management and improving clinical outcomes.

Comments

This is an open access thesis

Open Access

This Article is Open Access

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