Date of Award
Spring 4-19-2024
Document Type
Open Access Thesis
Degree Name
Master of Medical Science (MMSc)
First Advisor
Charles Wira, MD
Abstract
Targeted temperature management has been shown to improve neurologic status after cardiac arrest; however, recommendations for the timing of its initiation are unclear. Clinical trials have not directly studied time to targeted temperature management initiation, causing wide variability in protocol implementation. We propose a randomized, controlled, multi-center clinical trial to study the effect of early initiation of targeted temperature management in patients who achieve return of spontaneous circulation after out-of-hospital cardiac arrest. Data will be compared among patients who received initiation of targeted temperature management within 3 hours to those in whom initiation occurred after 3 hours. The primary outcome will be survival with favorable neurologic outcome, assessed at 6 months post-arrest with the use of the Cerebral Performance Category scale. These results may provide context for the interpretation of findings from previous trials in targeted temperature management, thereby potentially redefining guidelines for cardiac arrest management and improving clinical outcomes.
Recommended Citation
Liberti, Alexandra, "Targeted Temperature Management Device Initiation Time and Neurologic Outcomes After Cardiac Arrest" (2024). Yale School of Medicine Physician Associate Program Theses. 204.
https://elischolar.library.yale.edu/ysmpa_theses/204
Comments
This is an open access thesis