Date of Award

7-29-2022

Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Elena Ratner, MD

Second Advisor

Johanna D'Addario, MHS, PA-C

Abstract

Ovarian cancer is the most lethal gynecologic cancer. The leading risk factor for ovarian cancer is a family history of breast and/or ovarian cancer, but known genetic mutations contribute only a small percentage of heritable risk. Due to flawed early detection methods, risk management relies on prevention. Because some ovarian cancers originate in the fallopian tubes, researchers are exploring bilateral salpingectomy for risk reduction. However, utilization of the procedure has not been measured in patients with a documented ovarian cancer family history but no known genetic mutation. We aim to determine if a greater proportion of patients with an ovarian cancer family history will utilize bilateral salpingectomy for sterilization compared to those without a family history. Specifically, we will retrospectively review insurance claims data to examine the association between family history documentation and bilateral salpingectomy. The findings will help establish guidelines for risk reduction in families with ovarian cancer.

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