Date of Award
Open Access Thesis
Master of Medical Science (MMSc)
William Damsky, MD, PhD
Psoriasis is a common chronic inflammatory skin condition with no known cure. Intermittent fasting involves limiting caloric intake to designated time periods and decreases markers of systemic inflammation, but the clinical efficacy of intermittent fasting for patients with psoriasis remains unclear. We propose a randomized controlled clinical trial to investigate the clinical impact of adjunctive intermittent fasting on plaque psoriasis. Patients with mild to moderate plaque psoriasis will be managed with topical calcipotriene/betamethasone dipropionate cream and randomized to either practice daily intermittent fasting with an 8-hour eating window or practice a diet without time restriction. We hypothesize that patients engaging in intermittent fasting as an adjunct to calcipotriene/betamethasone dipropionate will exhibit a significant reduction in psoriasis severity compared to those managed with calcipotriene/betamethasone dipropionate alone. This study aims to address the need for evidence-based recommendations for patients considering intermittent fasting in the management of their mild to moderate psoriasis.
Queiroz, Grace, "Intermittent Fasting as Adjuvant to Topical Therapy in the Management of Mild to Moderate Psoriasis" (2022). Yale School of Medicine Physician Associate Program Theses. 139.
This Article is Open Access