Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Suguru Imaeda, MD


Melasma is a common hyperpigmentation disorder that negatively impacts quality of life. Melasma predominately affects women of reproductive age and is commonly acquired during pregnancy. Current treatment options focus on prevention with limited therapies available once melasma has developed for patients who are pregnant or breastfeeding. One potential therapy that has shown promise for the treatment of melasma is silymarin, a derivative of milk thistle. However, the effect of silymarin on melasma in the pregnant and breastfeeding population has never been investigated. This double-blind randomized placebo-controlled trial will investigate whether topical silymarin can improve the severity of melasma in pregnant and breastfeeding women. Outcomes will be measured using the Melasma Area Severity Index to assess changes from baseline. The results of this study will help inform providers about the use of silymarin for melasma management during pregnancy and may provide an additional therapy option.

Available for download on Saturday, May 20, 2023

Open Access

This Article is Open Access