Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Elliott Miller, MD, MHS


Survival rates for out-of-hospital cardiac arrest are abysmal and have largely remained unchanged over the last several decades. A recent single center study of patients with out-of-hospital cardiac arrest found that early cannulation with extracorporeal membrane oxygenation could improve mortality rates. It is unclear if these findings are generalizable to and reproducible at other hospitals. The goal of this study is to assess the rate of survival to hospital discharge for patients treated with early extracorporeal membrane oxygenation compared to standard advanced cardiovascular life support. To this end, we will conduct a multi-center, intention-to-treat, randomized controlled trial in adults with refractory ventricular fibrillation, out-of-hospital cardiac arrest, and transfer time to the hospital of less than thirty minutes. Our findings could further confirm extracorporeal membrane oxygenation as a promising intervention to increase survival for out-of-hospital cardiac arrest patients.

Available for download on Saturday, May 20, 2023

Open Access

This Article is Open Access