Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Charles Wira, MD


Minor ischemic strokes and transient ischemic attacks involve impaired perfusion to corresponding brain regions leading to neurological deficits that may or may not resolve after the event. Adults suffering one of these minor neurovascular events have high odds of a recurrent stroke within the first 90 days, mitigated but not prevented by standard treatment of clopidogrel and aspirin. Vitamin E alpha-tocopherols have been shown to reduce platelet aggregation, potentiate aspirin, and reduce ischemic damage. This study will assess the efficacy of vitamin E alpha-tocopherol, in addition to the standard treatment, on stroke recurrence in adults with a minor neurovascular event compared to the standard treatment alone. In this randomized, double-blinded, placebo-controlled trial, participants will receive the standard treatment of clopidogrel and aspirin with either vitamin E alpha-tocopherol or placebo supplements. This study may help decrease the proportion of stroke recurrence and may ultimately reduce morbidity and mortality.

Open Access

This Article is Open Access