Date of Award


Document Type

Open Access Thesis

Degree Name

Master of Medical Science (MMSc)

First Advisor

Mary Jane Minkin, MD


Bilateral Salpingo-Oophorectomies are offered to women with hereditary breast and ovarian cancer syndromes as prophylaxis to reduce the incidence of ovarian cancer. These surgeries induce acute surgical menopause and often result in compromised sexual function including decreased desire, sexual discomfort, and diminished sexual satisfaction. However, little is known about the differences in sexual function in women who undergo surgery with hysterectomy versus those that leave their uterus intact. Using a prospective cohort study, we will compare the effects of Bilateral Salpingo-Oophorectomy alone versus Bilateral Salpingo-Oophorectomy plus hysterectomy on sexual function in premenopausal women with breast cancer gene mutations. We will evaluate sexual function using several well-validated surveys including the Female Sexual Function Index. These insights will arm medical professionals and their patients with data on sexual outcomes and will help patients decide whether to include a hysterectomy in their cancer prevention plan.

Available for download on Saturday, July 01, 2023

Open Access

This Article is Open Access