Date of Award


Document Type


Degree Name

Master of Medical Science (MMSc)

First Advisor

Katherine Kohari, MD, FACOG


Preterm birth is the leading cause of morbidity and mortality in infants in the industrialized world. Common risk factors for preterm birth are a history of preterm birth, inflammation, and a short cervix. One treatment that has been shown to decrease inflammation and the incidence of preterm birth in women with a prior preterm birth and shortening cervices is progesterone supplementation. However, guidelines fail to account for nulliparous women at risk for preterm birth such as those with prior cervical conization. This study aims to conduct a randomized control trial to evaluate the efficacy of progesterone supplementation in the reduction of preterm birth in women with an increased risk of preterm birth due to their history of cervical conization. Results obtained from this study will help guide the counseling and management of nulliparous women with cervical conization and may help prevent preterm birth.