Date of Award


Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Dr. O. Donald Chrisman


[From the Discussion] In summary, we have shown that prostaglandin E1, when injected in the rabbit knee produces synovitis and cartilage matrix degradation. The finding that salicylate cannot prevent this degeneration whereas chloroquine can, is most likely due to their different mechanisms of action in this system. Whereas chloroquine's ability to stabilize membranes is protective int his experiment, salicylate's ability to prevent the biosynthesis of prostaglandins is by passed and therefore is not.


This is an Open Access Thesis

Open Access

This Article is Open Access