Five mammalian specimens from the late Paleocene Black Mingo Group, Berkeley County, South Carolina, represent the first occurrence of Paleocene land-mammals from the east coast of North America. A P3 or P4 represents the taeniodont Ectoganus gliriformis lobdelli, known previously only from the late Paleocene of western North America. A M1 or M2 represents Mingotherium holtae, new genus and species, a taxon which may be closely related to pseudictopids, uintatheres and xenungulates. A lower premolar or molar can only be classified as "Tribosphenida incertae sedis." A ?canine and a parietal can only be identified as "Mammalia incertae sedis."