Date of Award

January 2012

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Herbert Yu

Second Advisor

Xiaomei Ma

Abstract

Abstract

Object: To estimate the risk of endometrial cancer (EC) in association with intake of macronutrients from diet.

Design: A population-based case-control study conducted in Connecticut from 2004 to 2009

Method: Nutrient intake from diet was assessed by retrospective food frequency questionnaire. Multivariate unconditional logistic regression was used to estimate the EC risk in association with quartile levels of nutrient intake

Subjects: 583 women aged between 35-80 who were diagnosed with EC during 2004-2009 were enrolled in the study. Controls were identified by random digital dialing and matched to cases by age in frequency.

Results: The majority of macronutrients were not found to be associated with the risk of endometrial cancer. A significantly increased risk was shown in women who consumed high levels of trans-fat; compared to the lowest level OR for the third and forth quartiles=2.39, 2.43, respectively. In a multivariate-adjusted model, the ORs were attenuated to 1.93 and 1.75. A 60.5% or 53.4% decrease in risk was found in women with the highest quartile of alcohol drinking in energy- or multivariate-adjusted model, respectively.

Conclusions: The analysis suggests a positive relation between trans-fat intake and risk of EC and a protective effect of alcohol drinking on EC.

Comments

This is an Open Access Thesis.

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