Date of Award

January 2016

Document Type

Open Access Thesis

Degree Name

Master of Public Health (MPH)

Department

School of Public Health

First Advisor

Yawei Zhang

Abstract

Thyroid cancer (TC) incidence has increased greatly during the past decades with a few established risk factors. The relationship between diet factors and TC remains unclear. Limited literature has investigated the association and with inconsistent findings. We examined the association between dietary pattern and risk of TC in a population based case-control study conducted in Connecticut (2010-2011). 390 historically confirmed incident TC cases and 436 population-based controls that completed baseline dietary history questionnaires were included in the analyses. We identified 3 distinct dietary patterns (“Starchy Foods and Desserts”, “Fruits and Vegetables”, “High Protein and Fat”) through principal components analysis. Multivariate unconditional logistic regression models were used to investigate the association between dietary pattern and risk of TC, controlling for potential confounders. A diet rich in fruits and vegetables was significantly associated with a reduced risk of overall TC (OR=0.59, 95%CI: 0.39-0.90, Ptrend=0.023). Stronger protective effect with significant dose-response relationship was observed among women ≥ 50 years of age in risk of both overall TC (OR=0.45, 95%CI: 0.24-0.86, Ptrend=0.036) and papillary TC (OR=0.42, 95%CI: 0.21-0.84, Ptrend=0.031). A diet rich in starchy foods and dessert is positively associated with overall TC risk among men, and negatively associated with risk of TC among women. No significant associations were found between high protein and fat intake with risk of TC.

Comments

This is an Open Access Thesis.

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