Date of Award
Open Access Thesis
Medical Doctor (MD)
Dr. O. Donald Chrisman
[From the Discussion] In summary, we have shown that prostaglandin E1, when injected in the rabbit knee produces synovitis and cartilage matrix degradation. The finding that salicylate cannot prevent this degeneration whereas chloroquine can., is most likely due to their different mechanisms of action in this system. Whereas chloroquine's ability to stabilize membranes is protective int his experiment, salicylate's ability to prevent the biosynthesis of prostaglandins is by passed and therefore is not.
Teitz, Carol C., "The Effect of Salicylate and Chloroquine on Prostaglandin-Induced Articular Damage in the Rabbit Knee" (1974). Yale Medicine Thesis Digital Library. 526.