Date of Award

1-1-1971

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

Abstract

Perfusion studies carried out in 50 enucleated normal Rhesus eyes suggested that the trabecular meshwork is responsible for 60-65% of the resistance to aqueous outflow, that aqueous outflow pathways in the inner 1/3 to 1/2 of the sclera are responsible for about 25%, that pathways in the outer 1/2 to 2/3 of the sclera account for 10-15%, and that more distal path ways account for very little, if any resistance. An initial opening into Schlemm's canal increased the facility of outflow proportionally much more than did subsequent extension of the incision. Mean facility of aqueous outflow was found to be 0.52 ± 0.02 μl/min/mmHg at body temperature and at a mean experimental intraocular pressure of 8.0 mm Hg. A rough but definite inverse variation of outflow facility with intraocular pressure was observed over the range of experimental intraocular pressures (5.5-12.0 mm Hg).

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