Date of Award

4-1-1973

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Dr. Stuart Finch

Abstract

[From the Summary] Reactions of cellular hypersensitivity often involve the participation of different cell types. The communication between lymphocytes and polymorphonuclear leukocytes was investigated. Human sensitized lymphocytes exposed to old tuberculin were found to have a stimulatory effect of polymorphonuclear leukocytes as indicated by the latter's increased glucose-1-14c oxidation and lysozyme production. Similar results were obtained using lymphocytes non-specifically stimulated by phytohemagglutinin. Activation of lymphocytes required a latent period (24 hour) followed by rapid stimulation of polymorphonuclear leukocytes (2 ours). These results suggest that increased glucose-1-14c oxidation and lysozyme production may be related to enhanced microbicidal activity. A possible mechanism by which the postulated lymphocyte stimulation of polymorphonuclear leukocytes occurs is the secretion into the medium by the sensitized lymphocytes of a soluble substance which has biological activity. This activity may be due to a new material or it may be a function of one of the already described lymphocyte "factors".

Comments

This is an Open Access Thesis.

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