Date of Award

3-30-1982

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Dr. Ed C. Cadman

Second Advisor

Dr. James A. Waldron, Jr.

Third Advisor

Dr. Lee N. Newcomer

Abstract

Follicular center cell lymphoma with sclerosis is a significant clinicopathologic entity which has received little attention to date. Its uniqueness has been obscured by quarrels over classification of the non-Hodgkin's lymphomas; and by the reluctance of some to accept it as a bona fide pathologic subtype in the retroperitoneum, its most common site of presentation. This thesis examines the clinical and pathological findings in a series of 22 cases of retroperitoneal follicular center cell lymphoma with sclerosis obtained from the hematopathology files of Yale-New Haven Hospital. Background material on the immunobiology, classification, and staging of non-Hodgkin's lymphomas is provided; and comparisons with Idiopathic Retroperitoneal Fibrosis, nodular sclerosing Hodgkin's disease, and other retroperitoneal tumors are explored. A short term followup provides insight into the responsiveness of this malignancy to treatment and pinpoints prognostic risk factors.

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