Date of Award

January 2015

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Ji Liu

Subject Area(s)

Medicine

Abstract

This study compared the 24-hour intraocular pressure (IOP) related ocular dimensional profiles in untreated ocular hypertensive (OHTN) patients, healthy controls and untreated primary open angle glaucoma (POAG) patients using a contact lens sensor. Seventeen patients with OHTN, 16 age-matched controls and 16 untreated POAG patients underwent a 24-hour recording session with SENSIMED Triggerfish® (TF). Twenty-four hour TF profiles were normalized to TF artificial units (mV Eq) for analysis. OHTN patients were further stratified into glaucoma converters (n=5) and non-converters (n=12) using clinical criteria. We found that OHTN patients (age range: 34-79 years, 47% males, n=9) demonstrated a greater mean number of 24-hour TF peaks (17.6±6.5) compared to healthy controls (12.6±4.5, p=0.02) and POAG patients (13.4±3.7, p=0.03). OHTN patients showed more nocturnal TF peaks (6.9±3.6) compared to healthy controls (3.6±1.2, p=0.002) and POAG patients (4.2±1.6, p=0.01). The number of brief peaks (trough-to-peak time <30 minutes) in the nocturnal period was greater in OHTN patients (8.4±7.3) compared to healthy controls (4.4±3.7, p=0.009) and POAG patients (4.6±2.4, p=0.02). No significant differences in the 24-hour TF profiles were detected between converters and non-converters. We conclude that continuous 24-hour ocular dimensional profiles are different in OHTN patients compared to healthy controls and untreated POAG patients. OHTN patients exhibited a higher number of TF peaks compared to healthy controls and POAG patients. The majority of these peaks occurs during the nocturnal period and are brief in nature. Further work is needed to understand why ocular dimensional profiles differ between OHTN and POAG patients, and how these changes may affect the management of glaucoma.

Comments

This thesis is restricted to Yale network users only. This thesis is permanently embargoed from public release.

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