Date of Award

9-28-2010

Document Type

Open Access Thesis

Degree Name

Medical Doctor (MD)

First Advisor

Matthew R. Grossman, MD

Second Advisor

Howard Pearson

Abstract

NEONATAL ABSTINENCE SYNDROME: A RETROSPECTIVE REVIEW OF CLONIDINE AS AN ADJUNCT TO OPIOD TREATMENT. Joanna J. Schatz (Sponsored by Matthew R. Grossman). Department of Pediatrics, Yale University, School of Medicine, New Haven, CT. This was a retrospective medical record review of treatment for neonatal abstinence syndrome (NAS) due to in utero exposure to opioids. The purpose of our study was to determine if there was a difference in the duration of treatment between infants who received morphine alone compared to infants who were treated with both morphine and clonidine. We hypothesized that there would be a decrease in the duration of treatment in infants treated with both morphine and clonidine compared to infants treated with morphine alone. The primary outcome was duration of treatment for NAS. Medical records of infants born at Yale New Haven Hospital (YNHH) between January 2003 and December 2009 were reviewed. 117 infants met the inclusion criteria. 59 were treated with morphine, and 58 were treated with morphine and clonidine. The mean length of stay of infants treated with morphine and clonidine was significantly shorter than the mean length of stay of infants treated with morphine alone, 19.57 days (SD 9.896) and 25.14 days (SD 12.738) respectively (p<0.05). Both groups were similar with regard to infant demographic factors, and there was no significant difference in the maximum dose of diluted morphine in either treatment group (P=0.410). These results suggest that infants treated with morphine and clonidine for NAS have decreased lengths of pharmacotherapy compared to infants treated with morphine alone.

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