Date of Award

January 2012

Document Type

Thesis

Degree Name

Medical Doctor (MD)

Department

Medicine

First Advisor

Vikram Reddy

Subject Area(s)

Medicine, Epidemiology

Abstract

Colorectal cancer is represents a significant source of mortality and morbidity in the world. Even though genetic associations with the development of colorectal cancer have been noted, environmental factors and lifestyle appear to play a role in the pathogenesis of colorectal cancer development. Previous studies in the past have shown contrasting patterns of colorectal cancer risk among various ethnic groups in the United States, but to date none of them have compared an ethnic population's characteristics of colorectal cancer in the native country and in the migrated country. In this study, a retrospective evaluation was done of native Chinese colorectal cancer patients from 2008-2009 at Xiangya Second Hospital in Changsha, Hunan, China and Chinese American patients from 2007-2008 from the Surveillance, Epidemiology and End Results (SEER) database. We found that there was more rectal cancer as compared to colon cancer in Native Chinese as compared to Chinese Americans, as well as a younger age at presentation.

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